Sperm or Egg - a simple switch?
| Germ cells are identical in males and females. So what is the mechanism that leads germ cells in males to become sperm, and in females to become eggs? In a report "One big biology question solved" on a recent paper that will be published in Science, we see that the key factor seems to be the timing of when germ cell meiosis begins - before birth in females, after birth in males. And the trigger for meiosis is retinoic acid - a derivative of vitamin A. Male embryos show expression of a particular enzyme that obliterates retinoic acid, thereby suppressing meiosis until after birth. |









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